We analyzed the prognostic factors, such as sex, age, tumor shape, number, location, size, TNM stage, WHO grade, modified Bergkvist grade, treatemnt modality, cytology, type of progtression, mitotic activity index(MAI), volume corrected mitotic
index(M/V index) and pathologic grade, in a chort of 83 advanced transitional cell carcinoma of bladder who was followed for more than 3 years. N stage of TNM, WHO grade, modified Bergkvist grade and pathologic stage were related to mitotic
indices(p<0.05), but cytology was related to MAI only(p<0.05). In univariate analysis of prognostic factors, sex, N and M stage of TN, progression type, MAI & M/V index and pathologic stage were related to 5-year survival during follow up.
Multivariate
analysis of prognostic factors, which were signifiantly related in univariate analysis, identified MAI as the most important factor(p<0.05), followed by M/V index, n stage of TNM, sex, M stage of TNM and progression type. The result show that
advanced
transitional cell bladder tumors can be efficiently categorized into prognostic groups by quantitative mitotic frequency analysis.
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